Berkeley DB requires only underlying IEEE/ANSI Std 1003.1 (POSIX) system calls and can be ported easily to new architectures by adding stub routines to connect the native system interfaces to the Berkeley DB POSIX-style system calls. See the Berkeley DB Porting Guide for more information.

Berkeley DB will autoconfigure and run on almost any modern UNIX, POSIX or Linux systems, and on most historical UNIX platforms. Berkeley DB will autoconfigure and run on almost any GNU gcc toolchain-based embedded platform, including Cygwin, OpenLinux and others. See the Berkeley DB Installation and Build Guide for more information.

The Berkeley DB distribution includes support for QNX Neutrino. See the Berkeley DB Installation and Build Guide for more information.

The Berkeley DB distribution includes support for VxWorks. See the Berkeley DB Installation and Build Guide for more information.

The Berkeley DB distribution includes support for Windows/NT, Windows/2000 and Windows/XP, via the Microsoft Visual C++ 6.0 and .NET development environments. See the Berkeley DB Installation and Build Guide for more information.